Searchable abstracts of presentations at key conferences in endocrinology

ea0016s19.4 | Hormone receptors and adipose tissue | ECE2008

Adiponectin and its receptors in insulin resistance, diabetes, and metabolic syndrome, and obesity

Kadowaki Takashi

Adiponectin is a major insulin sensitizing hormone, which activates AMP kinase and PPARĪ± pathways to facilitate glucose and lipid metabolism to increase insulin sensitivity. Decreased plasma adiponectin linked to obesity is causally involved in insulin resistance and metabolic syndrome in obesity. Moreover, decreased plasma adiponectin is causally involved in atherosclerosis. In fact, decreased plasma adiponectin levels have been shown to be associated with future develop...

ea0043oc33 | Meta-Analysis of Phase 2/3 Studies | WCTD2016

Daytime napping, daytime sleepiness and the risk of metabolic diseases: dose-response meta-analysis

Yamada Tomohide , Shojima Nobuhiro , Yamauchi Toshimasa , Kadowaki Takashi

Background: Adequate sleep is important for good health, but it is not always easy to achieve because of social factors. Daytime napping is widely prevalent around the world. We recently published a meta-analysis, in which a J-shaped relationship was identified between naptime and cardiovascular diseases.Objective: In this research, we also performed a meta-analysis to investigate the association between daytime sleepiness or napping and the risk of meta...